Aciclovir

Lore & Background

It is a nucleoside analogue that mimics guanosine and works by decreasing the production of the virus's DNA. It is available as a generic medication and marketed under many brand names worldwide.

Reader's Guide

Aciclovir is significant for its role in treating herpes simplex virus infections, chickenpox, and shingles, and for preventing cytomegalovirus infections following transplant. It is generally considered safe for use in pregnancy and breastfeeding. Common side effects include nausea and diarrhea, while potentially serious side effects include kidney problems and low platelets. Greater care is recommended in those with poor liver or kidney function. Resistance is rare in healthy individuals but more common in immunocompromised patients on chronic antiviral prophylaxis. The drug is on the World Health Organization's List of Essential Medicines, underscoring its global importance.

Did You Know?

• It is a nucleoside analogue that mimics guanosine and works by decreasing the production of the virus's DNA.
• Common side effects include nausea and diarrhea; potentially serious side effects include kidney problems and low platelets.
• Resistance to aciclovir is rare in people with healthy immune systems but more common in immunocompromised individuals.